Shi, Na, Zhang, Xiaoxin, Zhu, Yin, Deng, Lihui, Li, Lan, Zhu, Ping, Xia, Liang, Jin, Tao, Ward, Thomas, Sztamary, Peter et al (show 14 more authors)
(2022)
Predicting persistent organ failure on admission in patients with acute pancreatitis: development and validation of a mobile nomogram.
HPB, 24 (11).
pp. 1907-1920.
Abstract
<h4>Background</h4>Early prediction of persistent organ failure (POF) is important for triage and timely treatment of patients with acute pancreatitis (AP).<h4>Methods</h4>All AP patients were consecutively admitted within 48 h of symptom onset. A nomogram was developed to predict POF on admission using data from a retrospective training cohort, validated by two prospective cohorts. The clinical utility of the nomogram was defined by concordance index (C-index), decision curve analysis (DCA), and clinical impact curve (CIC), while the performance by post-test probability.<h4>Results</h4>There were 816, 398, and 880 patients in the training, internal and external validation cohorts, respectively. Six independent predictors determined by logistic regression analysis were age, respiratory rate, albumin, lactate dehydrogenase, oxygen support, and pleural effusion and were included in the nomogram (web-based calculator: https://shina.shinyapps.io/DynNomapp/). This nomogram had reasonable predictive ability (C-indexes 0.88/0.91/0.81 for each cohort) and promising clinical utility (DCA and CIC). The nomogram had a positive likelihood ratio and post-test probability of developing POF in the training, internal and external validation cohorts of 4.26/31.7%, 7.89/39.1%, and 2.75/41%, respectively, superior or equal to other prognostic scores.<h4>Conclusions</h4>This nomogram can predict POF of AP patients and should be considered for clinical practice and trial allocation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Pancreatitis, Acute Disease, Prognosis, Nomograms, Retrospective Studies, Prospective Studies |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 18 Oct 2022 14:51 |
| Last Modified: | 18 Jan 2023 19:49 |
| DOI: | 10.1016/j.hpb.2022.05.1347 |
| Open Access URL: | https://doi.org/10.1016/j.hpb.2022.05.1347 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3165616 |
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