Targeted Therapies for Perihilar Cholangiocarcinoma

Gray, Simon ORCID: 0000-0001-8396-3328, Lamarca, Angela, Edeline, Julien, Klumpen, Heinz-Josef, Hubner, Richard A, McNamara, Mairead G and Valle, Juan W (2022) Targeted Therapies for Perihilar Cholangiocarcinoma. CANCERS, 14 (7). 1789-.

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Official URL: http://dx.doi.org/10.3390/cancers14071789

Abstract

Perihilar cholangiocarcinoma (pCCA) is the anatomical sub-group of biliary tract cancer (BTC) arising between the second-order intrahepatic bile ducts and the cystic duct. Together with distal and intrahepatic cholangiocarcinoma (dCCA and iCCA; originating distal to, and proximal to this, respectively), gallbladder cancer (GBC) and ampulla of Vater carcinoma (AVC), these clinicopathologically and molecularly distinct entities comprise biliary tract cancer (BTC). Most pCCAs are unresectable at diagnosis, and for those with resectable disease, surgery is extensive, and recurrence is common. Therefore, the majority of patients with pCCA will require systemic treatment for advanced disease. The prognosis with cytotoxic chemotherapy remains poor, driving interest in therapies targeted to the molecular nature of a given patient's cancer. In recent years, the search for efficacious targeted therapies has been fuelled both by whole-genome and epigenomic studies, looking to uncover the molecular landscape of CCA, and by specifically testing for aberrations where established therapies exist in other indications. This review aims to provide a focus on the current molecular characterisation of pCCA, targeted therapies applicable to pCCA, and future directions in applying personalised medicine to this difficult-to-treat malignancy.

Item Type:	Article
Uncontrolled Keywords:	perihilar, cholangiocarcinoma, pCCA, extrahepatic, targeted therapy, biliary tract cancer
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	18 Oct 2022 15:03
Last Modified:	18 Jan 2023 19:49
DOI:	10.3390/cancers14071789
Open Access URL:	https://www.mdpi.com/2072-6694/14/7/1789
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3165620