Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum



Tuekprakhon, Aekkachai, Nutalai, Rungtiwa, Dijokaite-Guraliuc, Aiste, Zhou, Daming, Ginn, Helen M, Selvaraj, Muneeswaran, Liu, Chang, Mentzer, Alexander J, Supasa, Piyada, Duyvesteyn, Helen ME
et al (show 26 more authors) (2022) Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum. CELL, 185 (14). 2422-+.

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Abstract

The Omicron lineage of SARS-CoV-2, which was first described in November 2021, spread rapidly to become globally dominant and has split into a number of sublineages. BA.1 dominated the initial wave but has been replaced by BA.2 in many countries. Recent sequencing from South Africa's Gauteng region uncovered two new sublineages, BA.4 and BA.5, which are taking over locally, driving a new wave. BA.4 and BA.5 contain identical spike sequences, and although closely related to BA.2, they contain further mutations in the receptor-binding domain of their spikes. Here, we study the neutralization of BA.4/5 using a range of vaccine and naturally immune serum and panels of monoclonal antibodies. BA.4/5 shows reduced neutralization by the serum from individuals vaccinated with triple doses of AstraZeneca or Pfizer vaccine compared with BA.1 and BA.2. Furthermore, using the serum from BA.1 vaccine breakthrough infections, there are, likewise, significant reductions in the neutralization of BA.4/5, raising the possibility of repeat Omicron infections.

Item Type: Article
Uncontrolled Keywords: OPTIC Consortium, ISARIC4C Consortium, Humans, Viral Vaccines, Antibodies, Viral, Neutralization Tests, South Africa, Antibodies, Neutralizing, COVID-19, SARS-CoV-2
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 18 Oct 2022 15:34
Last Modified: 18 Jan 2023 19:49
DOI: 10.1016/j.cell.2022.06.005
Open Access URL: https://doi.org/10.1016/j.cell.2022.06.005
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3165632