Late-onset seizures in a domestic shorthaired cat with global brain ischaemia and cortical laminar necrosis

Phillipps, Stephanie ORCID: 0000-0002-8061-4007, Schiborra, Frederike and Nagendran, Aran (2022) Late-onset seizures in a domestic shorthaired cat with global brain ischaemia and cortical laminar necrosis. VETERINARY RECORD CASE REPORTS, 10 (3).

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Official URL: http://dx.doi.org/10.1002/vrc2.374

Abstract

<jats:title>Abstract</jats:title><jats:p>The most common cause of global brain ischaemia in veterinary species is anaesthesia‐related cardiovascular dysfunction. Both early‐ and late‐onset seizures secondary to ischaemia are well recognised in human medicine, but late‐onset seizures have not been reported in veterinary species. A 2‐year‐old, female, neutered, domestic shorthaired cat with a history of blindness since ovariohysterectomy 10 months previously was presented for investigation of suspected seizure activity over the previous month. Neurological examination localised to generalised diffuse forebrain pathology. Magnetic resonance imaging was consistent with global brain ischaemia and suggestive of cortical laminar necrosis. The clinical history and imaging findings were consistent with historical perioperative cerebral hypoxia. Treatment with phenobarbitone resulted in excellent control of seizures. Anaesthesia accidents can occur during short, ‘routine’ procedures in apparently clinically healthy animals and may have severe long‐term effects for patients. This report suggests that late‐onset seizures can occur as a result of global brain ischaemia in veterinary species.</jats:p>

Item Type:	Article
Uncontrolled Keywords:	brain diseases, brain ischaemia, cats, neuroimaging, neurology, seizures
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	24 Oct 2022 09:23
Last Modified:	04 Sep 2023 03:16
DOI:	10.1002/vrc2.374
Open Access URL:	https://doi.org/10.1002/vrc2.374
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3165721