Impact of acute dynamic exercise and arterial shear rate modification on radial artery low-flow mediated constriction in young men

Alali, Mohammad H, Lucas, Rebekah AI, Junejo, Rehan T ORCID: 0000-0002-0670-8339 and Fisher, James P (2022) Impact of acute dynamic exercise and arterial shear rate modification on radial artery low-flow mediated constriction in young men. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 122 (8). pp. 1885-1895.

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Abstract

<h4>Purpose</h4>Leg cycling exercise acutely augments radial artery low-flow mediated constriction (L-FMC). Herein, we sought to determine whether this is associated with exercise-induced changes in arterial shear rate (SR).<h4>Methods</h4>Ten healthy and recreationally active young men (23 ± 2 years) participated in 30 min of incremental leg cycling exercise (50, 100, 150 Watts). Trials were repeated with (Exercise + WC) and without (Exercise) the use of a wrist cuff (75 mmHg) placed distal to the radial artery to increase local retrograde SR while reducing mean and anterograde SR. Radial artery characteristics were measured throughout the trial, and L-FMC and flow mediated dilatation (FMD) were assessed before and acutely (~ 10 min) after leg cycling.<h4>Results</h4>Exercise increased radial artery mean and anterograde SR, along with radial artery diameter, velocity, blood flow and conductance (P < 0.05). Exercise + WC attenuated the exercise-induced increase in mean and anterograde SR (P > 0.05) but also increased retrograde SR (P < 0.05). In addition, increases in radial artery blood flow and diameter were reduced during Exercise + WC (Exercise + WC vs. Exercise, P < 0.05). After Exercise, L-FMC was augmented (- 4.4 ± 1.4 vs. - 13.1 ± 1.6%, P < 0.05), compared to no change in L-FMC after Exercise + WC (- 5.2 ± 2.0 vs. - 3.0 ± 1.6%, P > 0.05). In contrast, no change in FMD was observed in either Exercise or Exercise + WC trials (P > 0.05).<h4>Conclusions</h4>These findings indicate that increases in L-FMC following exercise are abolished by the prevention of increases radial artery diameter, mean and anterograde SR, and by elevation of retrograde SR, during exercise in young men.

Item Type:	Article
Uncontrolled Keywords:	Low-flow mediated constriction, Leg cycling, Shear rate, Vascular function
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	26 Oct 2022 10:34
Last Modified:	18 Jan 2023 19:49
DOI:	10.1007/s00421-022-04963-x
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3165776