Boriani, Giuseppe, Vitolo, Marco 
ORCID: 0000-0002-5196-6249, Diemberger, Igor, Proietti, Marco ORCID: 0000-0003-1452-2478, Valenti, Anna Chiara, Malavasi, Vincenzo Livio and Lip, Gregory YH
(2021)
Optimizing indices of atrial fibrillation susceptibility and burden to evaluate atria fibrillation severity, risk and outcomes.
CARDIOVASCULAR RESEARCH, 117 (7).
pp. 1-21.
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Abstract
Atrial fibrillation (AF) has heterogeneous patterns of presentation concerning symptoms, duration of episodes, AF burden, and the tendency to progress towards the terminal step of permanent AF. AF is associated with a risk of stroke/thromboembolism traditionally considered dependent on patient-level risk factors rather than AF type, AF burden, or other characterizations. However, the time spent in AF appears related to an incremental risk of stroke, as suggested by the higher risk of stroke in patients with clinical AF vs. subclinical episodes and in patients with non-paroxysmal AF vs. paroxysmal AF. In patients with device-detected atrial tachyarrhythmias, AF burden is a dynamic process with potential transitions from a lower to a higher maximum daily arrhythmia burden, thus justifying monitoring its temporal evolution. In clinical terms, the appearance of the first episode of AF, the characterization of the arrhythmia in a specific AF type, the progression of AF, and the response to rhythm control therapies, as well as the clinical outcomes, are all conditioned by underlying heart disease, risk factors, and comorbidities. Improved understanding is needed on how to monitor and modulate the effect of factors that condition AF susceptibility and modulate AF-associated outcomes. The increasing use of wearables and apps in practice and clinical research may be useful to predict and quantify AF burden and assess AF susceptibility at the individual patient level. This may help us reveal why AF stops and starts again, or why AF episodes, or burden, cluster. Additionally, whether the distribution of burden is associated with variations in the propensity to thrombosis or other clinical adverse events. Combining the improved methods for data analysis, clinical and translational science could be the basis for the early identification of the subset of patients at risk of progressing to a longer duration/higher burden of AF and the associated adverse outcomes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Atrial fibrillation, AF susceptibility, Stroke, AF burden |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 26 Oct 2022 13:26 |
| Last Modified: | 18 Jan 2023 19:49 |
| DOI: | 10.1093/cvr/cvab147 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3165785 |
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