Role of antimicrobial peptides in atopic dermatitis



Suwanchote, Supaporn, Waitayangkoon, Palapun, Chancheewa, Bussabong, Inthanachai, Thananya, Niwetbowornchai, Nattarika, Edwards, Steven W ORCID: 0000-0002-7074-0552, Virakul, Sita, Thammahong, Arsa, Kiatsurayanon, Chanisa, Rerknimitr, Pawinee
et al (show 1 more authors) (2022) Role of antimicrobial peptides in atopic dermatitis. INTERNATIONAL JOURNAL OF DERMATOLOGY, 61 (5). pp. 532-540.

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Abstract

Host defense peptides (HDPs) or antimicrobial peptides (AMPs) are short cationic amphipathic peptides of divergent sequences, which are part of the innate immune system and produced by various types of cells and tissues. The predominant role of HDPs is to respond to and protect humans against infection and inflammation. Common human HDPs include defensins, cathelicidin, psoriasin, dermcidin, and ribonucleases, but these peptides may be dysregulated in the skin of patients with atopic dermatitis (AD). Current evidence suggests that the antimicrobial properties and immunomodulatory effects of HDPs are involved in AD pathogenesis, making HDPs research a promising area for predicting disease severity and developing novel treatments for AD. In this review, we describe a potential role for human HDPs in the development, exacerbation, and progression of AD and propose their potential therapeutic benefits.

Item Type: Article
Uncontrolled Keywords: Skin, Humans, Dermatitis, Atopic, Inflammation, Immunomodulation, Antimicrobial Peptides
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 01 Nov 2022 08:46
Last Modified: 18 Jan 2023 19:48
DOI: 10.1111/ijd.15814
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3165910