The Association between Serum Lipids and Intraocular Pressure in 2 Large United Kingdom Cohorts.

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Madjedi, Kian M, Stuart, Kelsey V ORCID: 0000-0001-7353-8774, Chua, Sharon YL, Luben, Robert N, Warwick, Alasdair, Pasquale, Louis R, Kang, Jae H, Wiggs, Janey L, Lentjes, Marleen AH, Aschard, Hugues et al (show 4 more authors) , Sattar, Naveed, Foster, Paul J, Khawaja, Anthony P and Modifiable Risk Factors for Glaucoma Collaboration and the UK Bi, (2022) The Association between Serum Lipids and Intraocular Pressure in 2 Large United Kingdom Cohorts. Ophthalmology, 129 (9). pp. 986-996.

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Abstract

<h4>Purpose</h4>Serum lipids are modifiable, routinely collected blood test features associated with cardiovascular health. We examined the association of commonly collected serum lipid measures (total cholesterol [TC], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], and triglycerides) with intraocular pressure (IOP).<h4>Design</h4>Cross-sectional study in the UK Biobank and European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohorts.<h4>Participants</h4>We included 94 323 participants from the UK Biobank (mean age, 57 years) and 6230 participants from the EPIC-Norfolk (mean age, 68 years) cohorts with data on TC, HDL-C, LDL-C, and triglycerides collected between 2006 and 2009.<h4>Methods</h4>Multivariate linear regression adjusting for demographic, lifestyle, anthropometric, medical, and ophthalmic covariables was used to examine the associations of serum lipids with corneal-compensated IOP (IOPcc).<h4>Main outcome measures</h4>Corneal-compensated IOP.<h4>Results</h4>Higher levels of TC, HDL-C, and LDL-C were associated independently with higher IOPcc in both cohorts after adjustment for key demographic, medical, and lifestyle factors. For each 1-standard deviation increase in TC, HDL-C, and LDL-C, IOPcc was higher by 0.09 mmHg (95% confidence interval [CI], 0.06-0.11 mmHg; P < 0.001), 0.11 mmHg (95% CI, 0.08-0.13 mmHg; P < 0.001), and 0.07 mmHg (95% CI, 0.05-0.09 mmHg; P < 0.001), respectively, in the UK Biobank cohort. In the EPIC-Norfolk cohort, each 1-standard deviation increase in TC, HDL-C, and LDL-C was associated with a higher IOPcc by 0.19 mmHg (95% CI, 0.07-0.31 mmHg; P = 0.001), 0.14 mmHg (95% CI, 0.03-0.25 mmHg; P = 0.016), and 0.17 mmHg (95% CI, 0.06-0.29 mmHg; P = 0.003). An inverse association between triglyceride levels and IOP in the UK Biobank (-0.05 mmHg; 95% CI, -0.08 to -0.03; P < 0.001) was not replicated in the EPIC-Norfolk cohort (P = 0.30).<h4>Conclusions</h4>Our findings suggest that serum TC, HDL-C, and LDL-C are associated positively with IOP in 2 United Kingdom cohorts and that triglyceride levels may be associated negatively. Future research is required to assess whether these associations are causal in nature.

Item Type:	Article
Uncontrolled Keywords:	Modifiable Risk Factors for Glaucoma Collaboration and the UK Biobank Eye and Vision Consortium, Humans, Triglycerides, Risk Factors, Prospective Studies, Cross-Sectional Studies, Intraocular Pressure, Aged, Middle Aged, Cholesterol, LDL, Cholesterol, HDL, United Kingdom
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	01 Nov 2022 16:28
Last Modified:	06 Sep 2023 16:53
DOI:	10.1016/j.ophtha.2022.04.023
Open Access URL:	https://doi.org/10.1016/j.ophtha.2022.04.023
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3165949