Selection of Relevant Bacterial Strains for Novel Therapeutic Testing: a Guidance Document for Priority Cystic Fibrosis Lung Pathogens

Mahenthiralingam, Eshwar, Weiser, Rebecca, Floto, R Andres, Davies, Jane C and Fothergill, Joanne L ORCID: 0000-0002-7012-1508 (2022) Selection of Relevant Bacterial Strains for Novel Therapeutic Testing: a Guidance Document for Priority Cystic Fibrosis Lung Pathogens. Current Clinical Microbiology Reports, 9 (4). pp. 33-45.

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Abstract

<jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose of Review</jats:title> <jats:p>People with cystic fibrosis (CF) suffer chronic lung infections with a range of antimicrobial-resistant bacterial pathogens. There is an urgent need for researchers to develop novel anti-infectives to treat these problematic infections, but how can we select bacterial strains which are relevant for robust testing and comparative research?</jats:p> </jats:sec><jats:sec> <jats:title>Recent Findings</jats:title> <jats:p><jats:italic>Pseudomonas aeruginosa</jats:italic>, <jats:italic>Burkholderia cepacia</jats:italic> complex and <jats:italic>Burkholderia gladioli</jats:italic>, <jats:italic>Mycobacterium abscessus</jats:italic> complex, <jats:italic>Staphylococcus aureus, Haemophilus influenza,</jats:italic> and several multidrug-resistant Gram-negative species were selected as key CF infections that urgently require new therapeutics. Reference isolates and strain panels were identified, and a summary of the known genotypic diversity of each pathogen was provided.</jats:p> </jats:sec><jats:sec> <jats:title>Summary</jats:title> <jats:p>Here, we summarise the current strain resources available for priority CF bacterial pathogens and highlight systematic selection criteria that researchers can use to select strains for use in therapeutic testing.</jats:p> </jats:sec>

Item Type:	Article
Uncontrolled Keywords:	Cystic fibrosis, Bacterial pathogens, Strain resources, Selection criteria
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	07 Nov 2022 09:17
Last Modified:	18 Jan 2023 19:43
DOI:	10.1007/s40588-022-00182-2
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3166006