A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer.

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Wu, Yin ORCID: 0000-0003-4080-3935, Biswas, Dhruva ORCID: 0000-0001-9141-5188, Usaite, Ieva, Angelova, Mihaela ORCID: 0000-0002-0495-9695, Boeing, Stefan, Karasaki, Takahiro ORCID: 0000-0001-6863-2360, Veeriah, Selvaraju, Czyzewska-Khan, Justyna, Morton, Cienne, Joseph, Magdalene et al (show 11 more authors) , Hessey, Sonya, Reading, James ORCID: 0000-0001-5381-978X, Georgiou, Andrew, Al-Bakir, Maise, TRACERx Consortium, , McGranahan, Nicholas, Jamal-Hanjani, Mariam ORCID: 0000-0003-1212-1259, Hackshaw, Allan ORCID: 0000-0002-5570-5070, Quezada, Sergio A ORCID: 0000-0002-9763-1700, Hayday, Adrian C ORCID: 0000-0002-9495-5793 and Swanton, Charles ORCID: 0000-0002-4299-3018 (2022) A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer. Nature cancer, 3 (6). pp. 696-709.

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Abstract

Murine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident γδ cells are less well defined. In the present study, we show that human lung tissues harbor a resident Vδ1 γδ T cell population. Moreover, we demonstrate that Vδ1 T cells with resident memory and effector memory phenotypes were enriched in lung tumors compared with nontumor lung tissues. Intratumoral Vδ1 T cells possessed stem-like features and were skewed toward cytolysis and helper T cell type 1 function, akin to intratumoral natural killer and CD8⁺ T cells considered beneficial to the patient. Indeed, ongoing remission post-surgery was significantly associated with the numbers of CD45RA^-CD27^- effector memory Vδ1 T cells in tumors and, most strikingly, with the numbers of CD103⁺ tissue-resident Vδ1 T cells in nonmalignant lung tissues. Our findings offer basic insights into human body surface immunology that collectively support integrating Vδ1 T cell biology into immunotherapeutic strategies for nonsmall cell lung cancer.

Item Type:	Article
Uncontrolled Keywords:	TRACERx Consortium, T-Lymphocyte Subsets, CD8-Positive T-Lymphocytes, Animals, Humans, Mice, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Receptors, Antigen, T-Cell, gamma-delta
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences > School of Medicine
Depositing User:	Symplectic Admin
Date Deposited:	08 Nov 2022 09:32
Last Modified:	18 Jan 2023 19:43
DOI:	10.1038/s43018-022-00376-z
Open Access URL:	https://doi.org/10.1038/s43018-022-00376-z
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3166041