Peacock, W Frank, Maisel, Alan S, Mueller, Christian, Anker, Stefan D, Apple, Fred S, Christenson, Robert H, Collinson, Paul 
ORCID: 0000-0002-7000-5996, Daniels, Lori B, Diercks, Deborah B, Di Somma, Salvatore et al (show 12 more authors)
(2022)
Finding acute coronary syndrome with serial troponin testing for rapid assessment of cardiac ischemic symptoms (FAST-TRAC): a study protocol.
CLINICAL AND EXPERIMENTAL EMERGENCY MEDICINE, 9 (2).
pp. 140-145.
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Abstract
<h4>Objective</h4>To determine the utility of a highly sensitive troponin assay when utilized in the emergency department.<h4>Methods</h4>The FAST-TRAC study prospectively enrolled >1,500 emergency department patients with suspected acute coronary syndrome within 6 hours of symptom onset and 2 hours of emergency department presentation. It has several unique features that are not found in the majority of studies evaluating troponin. These include a very early presenting population in whom prospective data collection of risk score parameters and the physician's clinical impression of the probability of acute coronary syndrome before any troponin data were available. Furthermore, two gold standard diagnostic definitions were determined by a pair of cardiologists reviewing two separate data sets; one that included all local troponin testing results and a second that excluded troponin testing so that diagnosis was based solely on clinical grounds. By this method, a statistically valid head-to-head comparison of contemporary and high sensitivity troponin testing is obtainable. Finally, because of a significant delay in sample processing, a unique ability to define the molecular stability of various troponin assays is possible.<h4>Trial registration</h4>ClinicalTrials.gov Identifier NCT00880802.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Acute coronary syndrome, Troponin, Emergency medicine, Myocardial infarction, Coronary artery disease |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 09 Nov 2022 11:08 |
| Last Modified: | 18 Jan 2023 19:43 |
| DOI: | 10.15441/ceem.21.154 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3166092 |
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