Bacteria, Lipopolysaccharides, Amyloid and the Role of Iron Dysregulation in Parkinson’s Disease

Vuuren, Marthinus Janse van, Nell, Theodore Albertus, Carr, Jonathan Ambrose, Kell, Douglas ORCID: 0000-0001-5838-7963 and Pretorius, Etheresia (2020) Bacteria, Lipopolysaccharides, Amyloid and the Role of Iron Dysregulation in Parkinson’s Disease. Biomolecules, 11 (1). 202011.0380.v1-.

Access the full-text of this item by clicking on the Open Access link.

Official URL: http://dx.doi.org/10.20944/preprints202011.0380.v1

Abstract

Neuronal lesions in Parkinson’s disease (PD) are commonly associated with α-synuclein (α-Syn)-induced cell damage that are present both in the central and peripheral nervous systems of patients, with the enteric nervous system also being especially vulnerable. Here we bring together evidence that the development and presence of PD depends on specific sets of interlinking factors that include neuro-inflammation, systemic inflammation, α-Syn-induced cell damage, vascular dysfunction, iron dysregulation, gut and periodontal dysbiosis. We argue that there is significant evidence that bacterial inflammagens fuel this systemic inflammation, and might be central to the development of PD. We also discuss the processes whereby lipopolysaccharides may be involved in causing nucleation of proteins, including of α-Syn. Lastly, we review evidence that pre-and probiotics, as well as antibiotics and faecal transplant treatment might be valuable treatments in PD. A most important consideration, however, is that these therapeutic options need to be validated and tested in randomized controlled clinical trials. However, targeting underlying mechanisms of PD, including gut dysbiosis and iron toxicity, have potentially opened up possibilities of a wide variety of novel treatments which may relieve the characteristic non-motor deficits of PD, and may even slow the progression and/or accompanying gut-related conditions of the disease.

Item Type:	Article
Uncontrolled Keywords:	Brain Disorders, Neurosciences, Neurodegenerative, Parkinson's Disease, Aging, 2 Aetiology, 2.1 Biological and endogenous factors, Neurological
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	09 Nov 2022 11:26
Last Modified:	15 Mar 2024 15:01
DOI:	10.3390/biom11010030
Open Access URL:	https://www.mdpi.com/2218-273X/11/1/30
Related URLs:	Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3166094