Esposito, Michela, Waltham, Chris, Taylor, Jonathan T 
ORCID: 0000-0001-8574-8322, Manger, Sam, Phoenix, Ben, Price, Tony, Poludniowski, Gavin, Green, Stuart, Evans, Philip M, Allport, Philip P et al (show 4 more authors)
(2018)
PRaVDA: The first solid-state system for proton computed tomography.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 55.
pp. 149-154.
Abstract
<h4>Purpose</h4>Proton CT is widely recognised as a beneficial alternative to conventional X-ray CT for treatment planning in proton beam radiotherapy. A novel proton CT imaging system, based entirely on solid-state detector technology, is presented. Compared to conventional scintillator-based calorimeters, positional sensitive detectors allow for multiple protons to be tracked per read out cycle, leading to a potential reduction in proton CT scan time. Design and characterisation of its components are discussed. An early proton CT image obtained with a fully solid-state imaging system is shown and accuracy (as defined in Section IV) in Relative Stopping Power to water (RSP) quantified.<h4>Method</h4>A solid-state imaging system for proton CT, based on silicon strip detectors, has been developed by the PRaVDA collaboration. The system comprises a tracking system that infers individual proton trajectories through an imaging phantom, and a Range Telescope (RT) which records the corresponding residual energy (range) for each proton. A back-projection-then-filtering algorithm is used for CT reconstruction of an experimentally acquired proton CT scan.<h4>Results</h4>An initial experimental result for proton CT imaging with a fully solid-state system is shown for an imaging phantom, namely a 75 mm diameter PMMA sphere containing tissue substitute inserts, imaged with a passively-scattered 125 MeV beam. Accuracy in RSP is measured to be ⩽1.6% for all the inserts shown.<h4>Conclusions</h4>A fully solid-state imaging system for proton CT has been shown capable of imaging a phantom with protons and successfully improving RSP accuracy. These promising results, together with system the capability to cope with high proton fluences (2×10<sup>8</sup> protons/s), suggests that this research platform could improve current standards in treatment planning for proton beam radiotherapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Proton therapy, Proton CT Elsevier, Solid state detectors |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 25 Nov 2022 10:40 |
| Last Modified: | 18 Jan 2023 19:43 |
| DOI: | 10.1016/j.ejmp.2018.10.020 |
| Open Access URL: | https://doi.org/10.1016/j.ejmp.2018.10.020 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3166374 |
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