Atrial Fibrillation and Stroke



Choi, Sylvia, Sagris, Dimitrios, Hill, Andrew, Lip, Gregory ORCID: 0000-0002-7566-1626 and Abdul Rahim, Azmil Husin ORCID: 0000-0002-1318-4027
(2023) Atrial Fibrillation and Stroke. Expert Review of Cardiovascular Therapy, 21 (1). pp. 35-56.

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Abstract

Introduction: Stroke is one of the leading causes of mortality and morbidity globally. Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. It is set to reach epidemic proportions. AF is associated with a five-fold increase in risk of stroke. Strokes caused by AF more often are fatal or result in severe disability. Even though the incidence of stroke has been significantly reduced by oral anticoagulation, AF is thought to account for a significant proportion of cryptogenic strokes where no etiology is identified. Areas covered: This article reviews the literature related to AF and stroke, pathophysiological insights, diagnosis of AF in stroke patients, and its management (Graphical Abstract). Expert opinion: The pathophysiology of thrombogenesis that links AF and stroke is not well understood and is an area of active research to identify new therapeutic targets to prevent AF and stroke. As the nature of AF and stroke is multifaceted, an integrated care approach to managing AF and stroke is increasingly essential.

Item Type: Article
Uncontrolled Keywords: atrial fibrillation, cryptogenic stroke, embolic stroke, integrated care approach, oral anticoagulation, rhythm control, stroke prevention
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 16 Dec 2022 09:09
Last Modified: 20 Dec 2023 02:30
DOI: 10.1080/14779072.2023.2160319
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3166708