Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight/obesity - the SWEET Project.


Gibbons, Catherine, O'Hara, Beverley, O'Connor, Dominic, Hardman, Charlotte ORCID: 0000-0002-0744-6019, Wilton, Moon ORCID: 0000-0003-4052-7918, Harrold, Joanne A ORCID: 0000-0002-0899-4586, Almiron-Roig, Eva, Navas-Carretero, Santiago, Hodgkins, Charo E, Nazare, Julie Anne et al (show 13 more authors) (2022) Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight/obesity - the SWEET Project. BMJ open, 12 (12). e063903-e063903.

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Abstract

<h4>Introduction</h4>Intake of free sugars in European countries is high and attempts to reduce sugar intake have been mostly ineffective. Non-nutritive sweeteners and sweetness enhancers (S&SEs) can maintain sweet taste in the absence of energy, but little is known about the impact of acute and repeated consumption of S&SE in foods on appetite. This study aims to evaluate the effect of acute and repeated consumption of two individual S&SEs and two S&SE blends in semisolid and solid foods on appetite and related behavioural, metabolic and health outcomes.<h4>Methods and analysis</h4>A work package of the SWEET Project; this study consists of five double-blind randomised cross-over trials which will be carried out at five sites across four European countries, aiming to have n=213. Five food matrices will be tested across three formulations (sucrose-sweetened control vs two reformulated products with S&SE blends and no added sugar). Participants (body mass index 25-35 kg/m<sup>2</sup>; aged 18-60 years) will consume each formulation for 14 days. The primary endpoint is composite appetite score (hunger, inverse of fullness, desire to eat and prospective food consumption) over a 3-hour postprandial incremental area under the curve during clinical investigation days on days 1 and 14.<h4>Ethics and dissemination</h4>The trial has been approved by national ethical committees and will be conducted in accordance with the Declaration of Helsinki. Results will be published in international peer-reviewed open-access scientific journals. Research data from the trial will be deposited in an open-access online research data archive.<h4>Trial registration number</h4>NCT04633681.

Item Type: Article
Uncontrolled Keywords: Protocols & guidelines, PUBLIC HEALTH, NUTRITION & DIETETICS, General endocrinology
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Population Health
Depositing User: Symplectic Admin
Date Deposited: 09 Jan 2023 11:46
Last Modified: 19 Apr 2023 04:12
DOI: 10.1136/bmjopen-2022-063903
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3166931
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