Increased Urinary IgA in Paediatric IgA Vasculitis Nephritis

Marro, Julien ORCID: 0000-0003-4954-7915, Chetwynd, Andrew J ORCID: 0000-0001-6648-6881, Edwards, Samuel, Wright, Rachael D ORCID: 0000-0002-7606-2297 and Oni, Louise ORCID: 0000-0002-1532-2390 (2022) Increased Urinary IgA in Paediatric IgA Vasculitis Nephritis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (23). 14548-.

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Official URL: http://dx.doi.org/10.3390/ijms232314548

Abstract

IgA vasculitis (IgAV) is the most common form of paediatric vasculitis, with up to 50% of patients experiencing kidney inflammation. Much remains unknown about IgAV, but it is believed to arise due to galactose-deficient IgA1 promoting an auto-inflammatory response. This study assesses whether urinary IgA can be detected in children with IgAV to allow further evaluation of IgA1 and whether it has any relationship with nephritis. Urinary and serum IgA concentrations were measured using commercially available ELISA kits. Patients were grouped into IgAV nephritis (IgAVN) or IgAV without nephritis (IgAVwoN). Fifty-nine children were included: IgAVN n = 12, IgAVwoN n = 35, and healthy controls (HC) n = 12, with a mean age of 8.2 ± 4.1 years. Urinary IgA concentrations were statistically significantly higher in patients with IgAV (107.1 ± 136.3 μg/mmol) compared to HC (50.6 ± 26.3 μg/mmol; p = 0.027) and IgAVN (229.8 ± 226.3 μg/mmol) compared to both IgAVwoN (65.0 ± 37.8 μg/mmol; p = 0.002) and HC (p < 0.001). Urinary IgA concentrations were able to distinguish between renal status (AUC 0.838, 95%CI [0.704−0.973], p < 0.001) and did not correlate with proteinuria (r = 0.124; p = 0.407). Urinary IgA concentrations are increased in children with IgAVN, and it has the potential to act as a non-invasive biofluid to further evaluate nephritis in this disease.

Item Type:	Article
Uncontrolled Keywords:	children, IgAV, IgAVN, kidney, paediatric, renal
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	16 Jan 2023 10:15
Last Modified:	22 Dec 2023 01:34
DOI:	10.3390/ijms232314548
Open Access URL:	https://doi.org/10.3390/ijms232314548
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3167044