Adverse Cardiovascular Events in Non-Traumatic Intracranial Hemorrhage and Ischemic Stroke Survivors

Pasi, Marco, Boulouis, Gregoire, Bisson, Arnaud ORCID: 0000-0002-3449-1800, Herbert, Julien, Bodin, Alexandre, Cordonnier, Charlotte, Lip, Gregory YH ORCID: 0000-0002-7566-1626 and Fauchier, Laurent (2022) Adverse Cardiovascular Events in Non-Traumatic Intracranial Hemorrhage and Ischemic Stroke Survivors. JOURNAL OF CLINICAL MEDICINE, 11 (23). 6885-.

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Official URL: http://dx.doi.org/10.3390/jcm11236885

Abstract

<h4>Background</h4>We aimed to evaluate different measures of adverse cardiovascular events between non-traumatic intracranial hemorrhage (ICrH) and ischemic stroke (IS) survivors with and without atrial fibrillation (AF).<h4>Methods</h4>Using a national hospitalization database we compared incidences and risks of all-cause in-hospital death, cardiovascular death, non-cardiovascular death, MACE-HF (in-hospital cardiovascular death, myocardial infarction, IS or new-onset heart failure [HF]) between ICrH and IS survivors with and without AF. Propensity-score matching was also performed.<h4>Results</h4>We identified 40,523 survivors of IS and 12,028 survivors of an ICrH without AF, and 20,449 IS survivors and 3574 ICrH survivors with AF. In unadjusted, adjusted and matched analyses, ICrH patients without AF had a higher risk of all-cause in-hospital death (Hazard Ratio (HR; for matched analyses) 1.80; 95% confidence interval (CI) 1.74-1.86), cardiovascular death (HR; 2.79; CI 2.64-2.94), MACE-HF (HR 1.97; CI 1.89-2.06) and new cerebrovascular events (HR 1.75; CI 1.57-1.96) but with lower risk of myocardial infarction (HR 0.81; CI 0.70-0.94), major bleeding (HR 0.92; CI 0.87-0.98) and new onset HF (HR 0.85; CI 0.79-0.91) compared to IS survivors without AF. Similar results were found for ICrH and IS survivors with AF except for myocardial infarction (HR 1.05; CI 0.79-1.34) and new onset HF (HR 0.94; CI 0.84-1.06) that were similar between the two groups.<h4>Conclusions</h4>Adverse cardiovascular events are more frequent in ICrH survivors compared to IS survivors. New onset HF is a relatively frequent event after ICrH, especially in those patients with comorbid atrial fibrillation.

Item Type:	Article
Uncontrolled Keywords:	atrial fibrillation, cardiovascular death, heart failure, intracranial hemorrhage, ischemic stroke, major cardiovascular event, myocardial infarction
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	18 Jan 2023 10:19
Last Modified:	27 Feb 2024 12:02
DOI:	10.3390/jcm11236885
Open Access URL:	https://doi.org/10.3390/jcm11236885
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3167113