Cardio- and Neurometabolic Adipobiology: Consequences and Implications for Therapy

Frohlich, Jan, Chaldakov, George N and Vinciguerra, Manlio ORCID: 0000-0002-1768-3894 (2021) Cardio- and Neurometabolic Adipobiology: Consequences and Implications for Therapy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (8). 4137-.

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Official URL: http://dx.doi.org/10.3390/ijms22084137

Abstract

Studies over the past 30 years have revealed that adipose tissue is the major endocrine and paracrine organ of the human body. Arguably, adiopobiology has taken its reasonable place in studying obesity and related cardiometabolic diseases (CMDs), including Alzheimer's disease (AD), which is viewed herein as a neurometabolic disorder. The pathogenesis and therapy of these diseases are multiplex at basic, clinical and translational levels. Our present goal is to describe new developments in cardiometabolic and neurometabolic adipobiology. Accordingly, we focus on adipose- and/or skeletal muscle-derived signaling proteins (adipsin, adiponectin, nerve growth factor, brain-derived neuroptrophic factor, neurotrophin-3, irisin, sirtuins, Klotho, neprilysin, follistatin-like protein-1, meteorin-like (metrnl), as well as growth differentiation factor 11) as examples of metabotrophic factors (MTFs) implicated in the pathogenesis and therapy of obesity and related CMDs. We argue that these pathologies are MTF-deficient diseases. In 1993 the "vascular hypothesis of AD" was published and in the present review we propose the "vasculometabolic hypothesis of AD." We discuss how MTFs could bridge CMDs and neurodegenerative diseases, such as AD. Greater insights on how to manage the MTF network would provide benefits to the quality of human life.

Item Type:	Article
Uncontrolled Keywords:	adipokines, adiponectin, Alzheimer&#8217, BDNF, cardiometabolic diseases, irisin, Klotho, metabotrophic factors, NGF, s disease
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	19 Jan 2023 09:52
Last Modified:	19 Jan 2023 09:52
DOI:	10.3390/ijms22084137
Open Access URL:	https://doi.org/10.3390/ijms22084137
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3167138