Dawson, Ellen A, Boidin, Maxime, Thompson, Ruth, Cable, Nigel T, Thijssen, Dick HJ and Green, Daniel J
(2021)
Impact of proximal and distal cuff inflation on brachial artery endothelial function in healthy individuals.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 121 (4).
pp. 1135-1144.
Abstract
<h4>Purpose</h4>In this study, we examined whether the decrease in endothelial function associated with short-term exposure to elevated retrograde shear rate (SR), could be prevented when combined with a concurrent drop in transmural pressure in humans.<h4>Methods</h4>Twenty-five healthy individuals reported to our laboratory on three occasions to complete 30-min experimental conditions, preceded and followed by assessment of endothelial function using flow-mediated dilation (FMD). We used cuff inflation for 30-min to manipulate retrograde SR and transmural pressure in the brachial artery. Subjects underwent, in randomised order: (1) forearm cuff inflation to 60 mmHg (distal cuff; causing increase in retrograde SR), (2) upper arm cuff inflation to 60 mmHg (proximal cuff; causing increase in retrograde SR + decrease in transmural pressure), and (3) no cuff inflation (Control).<h4>Results</h4>The distal and proximal cuff conditions both increased brachial artery retrograde SR (p < 0.001) and oscillatory shear index (p < 0.001). The Control intervention did not alter SR patterns or FMD (p > 0.05). A significant interaction-effect was found for FMD (p < 0.05), with the decrease during distal cuff (from 6.9 ± 2.3% to 6.1 ± 2.5%), being reversed to an increase with proximal cuff (from 6.3 ± 2.0 to 6.9 ± 2.0%). The proximal cuff-related increase in FMD could not be explained by the decrease in antegrade or increase in retrograde shear.<h4>Conclusion</h4>This study suggests that a decrease in transmural pressure may ameliorate the decline in endothelial function that occurs following exposure to elevated retrograde shear in healthy individuals.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Atherosclerosis, Vascular function, Shear stress, Hemodynamics |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 23 Jan 2023 10:12 |
| Last Modified: | 23 Jan 2023 10:12 |
| DOI: | 10.1007/s00421-021-04605-8 |
| Open Access URL: | https://researchonline.ljmu.ac.uk/id/eprint/14362/ |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3167793 |
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