Halimi, Jean-Michel, Gatault, Philippe 
ORCID: 0000-0003-1664-2879, Longuet, Hélène, Barbet, Christelle, Goumard, Annabelle, Gueguen, Juliette, Goin, Nicolas, Sautenet, Bénédicte, Herbert, Julien, Bisson, Arnaud ORCID: 0000-0002-3449-1800 et al (show 1 more authors)
(2021)
Major Bleeding of Transjugular Native Kidney Biopsies. A French Nationwide Cohort Study.
Kidney international reports, 6 (10).
pp. 2594-2603.
Abstract
<h4>Introduction</h4>The risk of bleeding associated with transjugular kidney biopsies is unclear, and which patients are the best candidates for this route is unknown.<h4>Methods</h4>This was a retrospective cohort study comparing proportion of bleeding associated with transjugular versus percutaneous native kidney biopsies in all patients in France in the 2010-2019 period. Major bleeding at day 8 (i.e., blood transfusions, hemorrhage/hematoma, angiographic intervention, nephrectomy) and risk of death at day 30 were assessed, and we used a bleeding risk score initially developed for the percutaneous route.<h4>Results</h4>Our analysis included 60,331 patients (transjugular route: 5305; percutaneous route: 55,026 patients). The observed proportion of major bleeding varied widely (transjugular vs. percutaneous): 0.4% versus 0.5% for the lowest risk scores (0-4) to 19.1% versus 30.8% for the highest risk scores (≥35). Transjugular was more frequently used than percutaneous route (39% vs. 24%) when the risk score was ≥20 (15,133/60,331; 25% of all patients). Transjugular was associated with a lower risk of major bleeding than percutaneous route in multivariate analyses (odds ratio [OR]: 0.88 [0.78-0.99]), especially for scores ≥20 (OR: 0.83 [0.72-0.96], (i.e., 25% of patients). Major bleeding was associated with an increased risk of death both for transjugular (OR: 1.77 [1.00-3.14]) and percutaneous (OR: 1.80 [1.43-2.28]) routes.<h4>Conclusions</h4>The transjugular route is independently associated with a lower risk of bleeding than the percutaneous route, especially in high-risk patients identified by a preprocedure risk score ≥20 (i.e., 25% of patients). Major bleeding is associated with an increased risk of death for both routes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | bleeding score, epidemiology, kidney biopsy, percutaneous, transjugular |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 24 Jan 2023 09:29 |
| Last Modified: | 18 Mar 2024 03:29 |
| DOI: | 10.1016/j.ekir.2021.07.011 |
| Open Access URL: | https://doi.org/10.1016/j.ekir.2021.07.011 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3167840 |
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