Ding, Wern Yew 
ORCID: 0000-0003-3596-6545, Davies, Ian G, Gupta, Dhiraj and Lip, Gregory YH ORCID: 0000-0002-7566-1626
(2022)
Relationship between Renal Function, Fibrin Clot Properties and Lipoproteins in Anticoagulated Patients with Atrial Fibrillation.
BIOMEDICINES, 10 (9).
2270-.
Abstract
<b>Background</b>: Mechanisms by which chronic kidney disease (CKD) influences fibrin clot properties in atrial fibrillation (AF) remain ill-defined. We aimed to investigate the effects of AF and CKD on fibrin clot properties and lipoproteins, and determine the relationship between these factors. <b>Methods</b>: Prospective cross-sectional study of patients recruited from cardiology services in Liverpool between September 2019 and October 2021. Primary groups consisted of anticoagulated AF patients with and without CKD in a 1:1 ratio. Control group comprised anticoagulated patients without AF or CKD. Fibrin clot properties were analysed using turbidity and permeation assays. Detailed lipoprotein characteristics, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), small dense LDL and oxidised LDL, were measured. <b>Results</b>: Fifty-six anticoagulated patients were enrolled (median age 72.5; 34% female); 46 with AF (23 with CKD and 23 without CKD) and 10 controls. AF was associated with changes in three indices of fibrin clot properties using PTT (T<sub>lag</sub> 314 vs. 358 s, <i>p</i> = 0.047; Abs<sub>peak</sub> 0.153 vs. 0.111 units, <i>p</i> = 0.031; T<sub>lysis50%</sub> 884 vs. 280 s, <i>p</i> = 0.047) and thrombin reagents (T<sub>lag</sub> 170 vs. 132 s, <i>p</i> = 0.031; T<sub>max</sub> 590 vs. 462 s, <i>p</i> = 0.047; T<sub>peak50%</sub> 406 vs. 220 s, <i>p</i> = 0.005) while the concomitant presence of CKD led to changes in fibrin clot properties using kaolin (T<sub>lag</sub> 1072 vs. 1640 s, <i>p</i> = 0.003; T<sub>max</sub> 1458 vs. 1962 s, <i>p</i> = 0.005; T<sub>peak50%</sub> 1294 vs. 2046, <i>p</i> = 0.008) and PPP reagents (T<sub>lag</sub> 566 vs. 748 s, <i>p</i> = 0.044). Neither of these conditions were associated with changes in fibrin clot permeability. Deteriorating eGFR was significantly correlated to the speed of clot formation, and CKD was independently associated with unfavourable clot properties (T<sub>lag</sub> -778, <i>p</i> = 0.002; T<sub>max</sub> -867, <i>p</i> = 0.004; T<sub>peak50%</sub> -853, <i>p</i> = 0.004 with kaolin reagent). AF alone was not associated with changes in lipoprotein distribution while AF patients with CKD had lower total cholesterol, LDL-C and small dense LDL due to the presence of other risk factors. No significant relationship was observed between fibrin clot properties and lipoprotein distribution. <b>Conclusions</b>: There are important changes that occur in fibrin clot properties with AF and CKD that may account for the increased risk of thromboembolic complications. However, these changes in fibrin clot properties were not attributable to alterations in lipoprotein distribution.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | chronic kidney disease, turbidimetry, low-density lipoprotein, small dense low-density lipoprotein, oxidised low-density lipoprotein |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 30 Jan 2023 09:26 |
| Last Modified: | 30 Jan 2023 09:26 |
| DOI: | 10.3390/biomedicines10092270 |
| Open Access URL: | https://doi.org/10.3390/biomedicines10092270 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3167952 |
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