Systemic depletion of histone macroH2A1.1 boosts hippocampal synaptic plasticity and social behavior in mice

Chiodi, Valentina, Domenici, Maria Rosaria, Biagini, Tommaso, De Simone, Roberta, Tartaglione, Anna Maria, Di Rosa, Michelino, Lo Re, Oriana, Mazza, Tommaso, Micale, Vincenzo and Vinciguerra, Manlio ORCID: 0000-0002-1768-3894 (2021) Systemic depletion of histone macroH2A1.1 boosts hippocampal synaptic plasticity and social behavior in mice. FASEB JOURNAL, 35 (8). e21793-.

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Official URL: http://dx.doi.org/10.1096/fj.202100569r

Abstract

Gene expression and epigenetic processes in several brain regions regulate physiological processes such as cognitive functions and social behavior. MacroH2A1.1 is a ubiquitous variant of histone H2A that regulates cell stemness and differentiation in various organs. Whether macroH2A1.1 has a modulatory role in emotional behavior is unknown. Here, we employed macroH2A1.1 knock-out (<sup>-/-</sup> ) mice to perform a comprehensive battery of behavioral tests, and an assessment of hippocampal synaptic plasticity (long-term potentiation) accompanied by whole hippocampus RNA sequencing. MacroH2A1.1<sup>-/-</sup> mice exhibit a stunningly enhancement both of sociability and of active stress-coping behavior, reflected by the increased social behavior in social activity tests and higher mobility time in the forced swim test, respectively. They also display an increased hippocampal synaptic plasticity, accompanied by significant neurotransmission transcriptional networks changes. These results suggest that systemic depletion of histone macroH2A1.1 supports an epigenetic control necessary for hippocampal function and social behavior.

Item Type:	Article
Uncontrolled Keywords:	epigenetics, hippocampus, 1, social behavior
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	31 Jan 2023 09:06
Last Modified:	31 Jan 2023 09:06
DOI:	10.1096/fj.202100569R
Open Access URL:	https://doi.org/10.1096/fj.202100569R
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3167978