The Defibrillation Conundrum: New Insights into the Mechanisms of Shock-Related Myocardial Injury Sustained from a Life-Saving Therapy

Clementy, Nicolas, Bodin, Alexandre, Bisson, Arnaud ORCID: 0000-0002-3449-1800, Teixeira-Gomes, Ana-Paula, Roger, Sebastien, Angoulvant, Denis, Labas, Valerie and Babuty, Dominique (2021) The Defibrillation Conundrum: New Insights into the Mechanisms of Shock-Related Myocardial Injury Sustained from a Life-Saving Therapy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (9). 5003-.

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Official URL: http://dx.doi.org/10.3390/ijms22095003

Abstract

Implantable cardiac defibrillators (ICDs) are recommended to prevent the risk of sudden cardiac death. However, shocks are associated with an increased mortality with a dose response effect, and a strategy of reducing electrical therapy burden improves the prognosis of implanted patients. We review the mechanisms of defibrillation and its consequences, including cell damage, metabolic remodeling, calcium metabolism anomalies, and inflammatory and pro-fibrotic remodeling. Electrical shocks do save lives, but also promote myocardial stunning, heart failure, and pro-arrhythmic effects as seen in electrical storms. Limiting unnecessary implantations and therapies and proposing new methods of defibrillation in the future are recommended.

Item Type:	Article
Uncontrolled Keywords:	defibrillation, electrical, injury, mechanism, proteomics, shock
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	31 Jan 2023 09:05
Last Modified:	31 Jan 2023 09:05
DOI:	10.3390/ijms22095003
Open Access URL:	https://doi.org/10.3390/ijms22095003
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3167983