Boidin, Maxime, Dawson, Ellen A, Thijssen, Dick HJ and Erskine, Robert M
(2023)
<i>VEGFA</i> rs2010963 GG genotype is associated with superior adaptations to resistance <i>versus</i> endurance training in the same group of healthy, young men.
MOLECULAR GENETICS AND GENOMICS, 298 (1).
pp. 119-129.
Abstract
<h4>Purpose</h4>We used a within-subject, cross-over study to determine the relationship between the intra-individual adaptations to four weeks' resistance (RT) versus four weeks' endurance (END) training, and we investigated whether three single nucleotide polymorphisms (SNPs) were associated with these adaptations.<h4>Methods</h4>Thirty untrained, healthy, young men completed a cycling test to exhaustion to determine peak oxygen uptake (V̇O<sub>2peak</sub>), and a knee extension (KE) maximum voluntary isometric contraction (MVIC) of the right leg before and after four weeks' supervised RT (four sets of 10 repetitions at 80% single repetition maximum unilateral KE exercise, three times weekly) and four weeks' supervised END (30 min combined continuous/interval cycling, three times weekly), separated by a three-week washout phase. Participants were genotyped for the ACTN3 rs1815739, NOS3 rs2070744 and VEGFA rs2010963 SNPs.<h4>Results</h4>The intra-individual adaptations regarding percentage changes in MVIC force and V̇O<sub>2peak</sub> following RT and END, respectively, were unrelated (r<sup>2</sup> = 0.003; P = 0.79). However, a VEGFA genotype × training modality interaction (P = 0.007) demonstrated that VEGFA GG homozygotes increased their MVIC force after RT (+ 20.9 ± 13.2%) more than they increased their V̇O<sub>2peak</sub> after END (+ 8.4 ± 9.1%, P = 0.005), and more than VEGFA C-allele carriers increased their MVIC force after RT (+ 12.2 ± 8.1%, P = 0.04). There were no genotype × training modality interactions for the ACTN3 or NOS3 SNPs.<h4>Conclusion</h4>High/low responders to RT were not consequently high/low responders to END or vice versa. However, preferential adaptation of VEGFA rs2010963 GG homozygotes to RT over END, and their greater adaptation to RT compared to VEGFA C-allele carriers, indicate a novel genetic predisposition for superior RT adaptation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Aerobic training, Strength training, Genetic variation, Training response, Maximal force |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 31 Jan 2023 09:05 |
| Last Modified: | 18 Oct 2023 09:08 |
| DOI: | 10.1007/s00438-022-01965-4 |
| Open Access URL: | https://doi.org/10.1007/s00438-022-01965-4 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3167987 |
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