De Nucci, Sara, Castellana, Fabio, Zupo, Roberta, Lampignano, Luisa, Di Chito, Martina, Rinaldi, Roberta, Giannuzzi, Vito, Cozzolongo, Raffaele, Piazzolla, Giuseppina, Giannelli, Gianluigi et al (show 2 more authors)
(2022)
Associations between serum biomarkers and non-alcoholic liver disease: Results of a clinical study of Mediterranean patients with obesity.
FRONTIERS IN NUTRITION, 9.
1002669-.
Abstract
<h4>Background</h4>Transient elastography is an ultrasound-based method to detect non-alcoholic fatty liver disease (NAFLD). Despite the simultaneously rising prevalence of fatty liver and metabolic disease, further information about metabolic risk indicators of fatty liver is still necessary.<h4>Methods</h4>A Southern Italian population sample with obesity (<i>N</i> = 87) was cross-sectionally explored for associations among the presence of NAFLD, assessed by FibroScan, and clinical, biochemical and anthropometric parameters. Inclusion criteria were age >18 years, BMI ≥ 25 kg/m<sup>2</sup>, no ongoing supplemental or drug therapy, including oral contraceptives or osteoporosis medications; exclusion criteria were pregnancy, endocrinological diseases, cardiovascular diseases, neoplasia, renal or hepatic failure, hereditary thrombocytopenia, hepatitis B (HBV) or hepatitis C virus (HCV) infection, and excess alcohol consumption.<h4>Results</h4>The study sample featured a female predominance (67%, <i>N</i> = 60), age range 18-64 years, and 40% prevalence of NAFLD, in accordance with the fibroscan-measured controlled attenuation parameter (CAP) threshold value above 302 dB/m. Males were slightly more frequently affected by NAFLD (51.4% vs. 48.6%, <i>p</i> = 0.01). Insulin levels, insulin resistance (quantified by HOMA-IR), diastolic blood pressure, BMI, visceral adipose tissue (VAT), and waist circumference were significantly higher in the NAFLD subset compared to their counterparts (<i>p</i> < 0.01, <i>p</i> < 0.01, <i>p</i> = 0.05, <i>p</i> < 0.01, <i>p</i> < 0.01, <i>p</i> < 0.01, respectively). Uric acid (<i>p</i> < 0.01) also showed a positive trend in the NAFLD group. Other liver steatosis parameters, measured by stiffness (<i>p</i> < 0.01), fatty liver index (FLI) (<i>p</i> < 0.01) and FibroScan-AST (FAST) (<i>p</i> < 0.01), were also significantly greater in the NAFLD group. In three nested linear regression models built to assess associations between CAP values and serum uric acid levels, a single unit increase in uricemia indicated a CAP increase by 14 dB/m, after adjusting for confounders (coefficient: 14.07, 95% CI 0.6-27.54).<h4>Conclusions</h4>Clinical-metabolic screening for NAFLD cannot ignore uricemia, especially in patients with obesity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | fatty liver, NAFLD, transient elastography, obesity, cross sectional analysis |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 01 Feb 2023 11:08 |
| Last Modified: | 27 Apr 2023 12:13 |
| DOI: | 10.3389/fnut.2022.1002669 |
| Open Access URL: | https://doi.org/10.3389/fnut.2022.1002669 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3168061 |
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