De Nucci, Sara, Zupo, Roberta, Donghia, Rossella, Castellana, Fabio, Lofu, Domenico, Aresta, Simona, Guerra, Vito, Bortone, Ilaria, Lampignano, Luisa, De Pergola, Giovanni et al (show 7 more authors)
(2023)
Dietary profiling of physical frailty in older age phenotypes using a machine learning approach: the Salus in Apulia Study.
EUROPEAN JOURNAL OF NUTRITION, 62 (3).
pp. 1217-1229.
Abstract
<h4>Purpose</h4>Growing awareness of the biological and clinical value of nutrition in frailty settings calls for further efforts to investigate dietary gaps to act sooner to achieve focused management of aging populations. We cross-sectionally examined the eating habits of an older Mediterranean population to profile dietary features most associated with physical frailty.<h4>Methods</h4>Clinical and physical examination, routine biomarkers, medical history, and anthropometry were analyzed in 1502 older adults (65 +). CHS criteria were applied to classify physical frailty, and a validated Food Frequency Questionnaire to assess diet. The population was subdivided by physical frailty status (frail or non-frail). Raw and adjusted logistic regression models were applied to three clusters of dietary variables (food groups, macronutrients, and micronutrients), previously selected by a LASSO approach to better predict diet-related frailty determinants.<h4>Results</h4>A lower consumption of wine (OR 0.998, 95% CI 0.997-0.999) and coffee (OR 0.994, 95% CI 0.989-0.999), as well as a cluster of macro and micronutrients led by PUFAs (OR 0.939, 95% CI 0.896-0.991), zinc (OR 0.977, 95% CI 0.952-0.998), and coumarins (OR 0.631, 95% CI 0.431-0.971), was predictive of non-frailty, but higher legumes intake (OR 1.005, 95%CI 1.000-1.009) of physical frailty, regardless of age, gender, and education level.<h4>Conclusions</h4>Higher consumption of coffee and wine, as well as PUFAs, zinc, and coumarins, as opposed to legumes, may work well in protecting against a physical frailty profile of aging in a Mediterranean setting. Longitudinal investigations are needed to better understand the causal potential of diet as a modifiable contributor to frailty during aging.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Food intake, Dietary habits, Mediterranean diet, Salus in Apulia Study, Older population, Physical frailty |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 02 Feb 2023 09:36 |
| Last Modified: | 08 Jun 2023 12:13 |
| DOI: | 10.1007/s00394-022-03066-9 |
| Open Access URL: | https://doi.org/10.1007/s00394-022-03066-9 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3168090 |
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