Bio-chemo-mechanics of the thoracic aorta.

Iddawela, Sashini, Ravendren, Andrew and Harky, Amer ORCID: 0000-0001-5507-5841 (2021) Bio-chemo-mechanics of the thoracic aorta. Vascular biology (Bristol, England), 3 (1). R25-R33.

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Abstract

The pathophysiology of thoracic aortic aneurysm and dissection is poorly understood, despite high mortality. An evidence review was conducted to examine the biomechanical, chemical and genetic factors involved in thoracic aortic pathology. The composition of connective tissue and smooth muscle cells can mediate important mechanical properties that allow the thoracic aorta to withstand and transmit pressures. Genetic syndromes can affect connective tissue and signalling proteins that interrupt smooth muscle function, leading to tissue failure. There are complex interplaying factors that maintain thoracic aortic function in health and are disrupted in disease, signifying an area for extensive research.

Item Type:	Article
Uncontrolled Keywords:	aorta, biomechanics, shear stress, vascular vessel
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	02 Feb 2023 15:24
Last Modified:	02 Feb 2023 15:25
DOI:	10.1530/vb-20-0015
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3168107