Chang, Wenguang, Wang, Man, Zhang, Yuan, Yu, Fei, Hu, Bin, Goljanek-Whysall, Katarzyna 
ORCID: 0000-0001-8166-8800 and Li, Peifeng
(2022)
Roles of long noncoding RNAs and small extracellular vesicle-long noncoding RNAs in type 2 diabetes.
TRAFFIC, 23 (11).
pp. 526-537.
Abstract
The prevalence of a high-energy diet and a sedentary lifestyle has increased the incidence of type 2 diabetes (T2D). T2D is a chronic disease characterized by high blood glucose levels and insulin resistance in peripheral tissues. The pathological mechanism of this disease is not fully clear. Accumulated evidence has shown that noncoding RNAs have an essential regulatory role in the progression of diabetes and its complications. The roles of small noncoding RNAs, such as miRNAs, in T2D, have been extensively investigated, while the function of long noncoding RNAs (lncRNAs) in T2D has been unstudied. It has been reported that lncRNAs in T2D play roles in the regulation of pancreatic function, peripheral glucose homeostasis and vascular inflammation. In addition, lncRNAs carried by small extracellular vesicles (sEV) were shown to mediate communication between organs and participate in diabetes progression. Some sEV lncRNAs derived from stem cells are being developed as potential therapeutic agents for diabetic complications. In this review, we summarize the current knowledge relating to lncRNA biogenesis, the mechanisms of lncRNA sorting into sEV and the regulatory roles of lncRNAs and sEV lncRNAs in diabetes. Knowledge of lncRNAs and sEV lncRNAs in diabetes will aid in the development of new therapeutic drugs for T2D in the future.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | diabetes, exosomes, long noncoding RNA, small extracellular vesicle, sorting mechanism |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 03 Feb 2023 10:29 |
| Last Modified: | 03 Feb 2023 10:29 |
| DOI: | 10.1111/tra.12868 |
| Open Access URL: | https://doi.org/10.1111/tra.12868 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3168143 |
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