Neural correlates of neuroticism: A coordinate-based meta-analysis of resting-state functional brain imaging studies

Lin, Jinping, Li, Lei, Pan, Nanfang, Liu, Xiqin, Zhang, Xun, Suo, Xueling, Kemp, Graham J ORCID: 0000-0002-8324-9666, Wang, Song and Gong, Qiyong (2023) Neural correlates of neuroticism: A coordinate-based meta-analysis of resting-state functional brain imaging studies. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 146. 105055-.

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Official URL: http://dx.doi.org/10.1016/j.neubiorev.2023.105055

Abstract

Neuroticism is one of the most robust higher-order personality traits associated with negative emotionality and risk of mental disorders. Many studies have investigated relationships between neuroticism and the brain, but the results have been inconsistent. We conducted a meta-analysis of whole-brain resting-state functional neuroimaging studies to identify the most stable neurofunctional substrates of neuroticism. We found stable significant positive correlations between neuroticism and resting-state brain activity in the left middle temporal gyrus (MTG), left striatum, and right hippocampus. In contrast, resting-state brain activity in the left superior temporal gyrus (STG) and right supramarginal gyrus (SMG) was negatively associated with neuroticism. Additionally, meta-regression analysis revealed brain regions in which sex and age moderated the link of spontaneous activity with neuroticism. This is the first study to provide a comprehensive understanding of resting-state brain activity correlates of neuroticism, and the findings may be useful for the targeting of specific brain regions for interventions to decrease the risks of mental health problems.

Item Type:	Article
Uncontrolled Keywords:	Neuroticism personality, Neuroscience, Resting-state functional brain imaging, Meta-analysis, Mental disorders, Psychoradiology
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	06 Feb 2023 10:35
Last Modified:	08 Mar 2023 18:57
DOI:	10.1016/j.neubiorev.2023.105055
Open Access URL:	https://www.sciencedirect.com/science/article/pii/...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3168204