Adaptation of the transcriptional response to resistance exercise over 4 weeks of daily training

Viggars, Mark R, Sutherland, Hazel, Lanmueller, Hermann, Schmoll, Martin, Bijak, Manfred and Jarvis, Jonathan C (2023) Adaptation of the transcriptional response to resistance exercise over 4 weeks of daily training. FASEB JOURNAL, 37 (1). e22686-.

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Abstract

We present the time course of change in the muscle transcriptome 1 h after the last exercise bout of a daily resistance training program lasting 2, 10, 20, or 30 days. Daily exercise in rat tibialis anterior muscles (5 sets of 10 repetitions over 20 min) induced progressive muscle growth that approached a new stable state after 30 days. The acute transcriptional response changed along with progressive adaptation of the muscle phenotype. For example, expression of type 2B myosin was silenced. Time courses recently synthesized from human exercise studies do not demonstrate so clearly the interplay between the acute exercise response and the longer-term consequences of repeated exercise. We highlight classes of transcripts and transcription factors whose expression increases during the growth phase and declines again as the muscle adapts to a new daily pattern of activity and reduces its rate of growth. Myc appears to play a central role.

Item Type:	Article
Uncontrolled Keywords:	Muscles, Animals, Humans, Rats, Acclimatization, Phenotype, Resistance Training, Physical Conditioning, Human
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	06 Feb 2023 10:35
Last Modified:	09 Sep 2023 02:27
DOI:	10.1096/fj.202201418R
Open Access URL:	https://doi.org/10.1096/fj.202201418R
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3168207