Investigation of MicroRNA Biomarkers in Equine Distal Interphalangeal Joint Osteoarthritis

Baker, Melissa EE, Lee, Seungmee, Clinton, Michael, Hackl, Matthias, Castanheira, Catarina, Peffers, Mandy JJ ORCID: 0000-0001-6979-0440 and Taylor, Sarah EE (2022) Investigation of MicroRNA Biomarkers in Equine Distal Interphalangeal Joint Osteoarthritis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (24). 15526-.

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Official URL: http://dx.doi.org/10.3390/ijms232415526

Abstract

Osteoarthritis of the equine distal interphalangeal joint is a common cause of lameness. MicroRNAs from biofluids are promising biomarkers and therapeutic candidates. Synovial fluid samples from horses with mild and severe equine distal interphalangeal joint osteoarthritis were submitted for small RNA sequencing. The results demonstrated that miR-92a was downregulated in equine synovial fluid from horses with severe osteoarthritis and there was a significant increase in COMP, COL1A2, RUNX2 and SOX9 following miR-92a mimic treatment of equine chondrocytes in monolayer culture. This is the first equine study to evaluate the role of miR-92a in osteoarthritic chondrocytes in vitro.

Item Type:	Article
Uncontrolled Keywords:	biomarkers, distal interphalangeal joint, equine, microRNA, osteoarthritis, synovial fluid
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	07 Feb 2023 09:43
Last Modified:	13 Oct 2023 20:44
DOI:	10.3390/ijms232415526
Open Access URL:	https://doi.org/10.3390/ijms232415526
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3168235