Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression

Sun, Changye, Tian, Xiangqin, Jia, Yangyang, Yang, Mingming, Li, Yong and Fernig, David G ORCID: 0000-0003-4875-4293 (2022) Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression. OPEN BIOLOGY, 12 (9). 210356-.

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Abstract

Fibroblasts are widely distributed cells found in most tissues and upon tissue injury, they are able to differentiate into myofibroblasts, which express abundant extracellular matrix (ECM) proteins. Overexpression and unordered organization of ECM proteins cause tissue fibrosis in damaged tissue. Fibroblast growth factor (FGF) family proteins are well known to promote angiogenesis and tissue repair, but their activities in fibroblast differentiation and fibrosis have not been systematically reviewed. Here we summarize the effects of FGFs in fibroblast to myofibroblast differentiation and ECM protein expression and discuss the underlying potential regulatory mechanisms, to provide a basis for the clinical application of recombinant FGF protein drugs in treatment of tissue damage.

Item Type:	Article
Uncontrolled Keywords:	FGF signalling, TGF-beta signalling, fibrosis, ECM proteins, tissue repair, fibroblast activation
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	07 Feb 2023 11:20
Last Modified:	07 Feb 2023 11:21
DOI:	10.1098/rsob.210356
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3168246