micro(RNA)-managing muscle wasting.

Sannicandro, Anthony J, Soriano-Arroquia, Ana and Goljanek-Whysall, Katarzyna ORCID: 0000-0001-8166-8800 (2019) micro(RNA)-managing muscle wasting. Journal of applied physiology (Bethesda, Md. : 1985), 127 (2). pp. 619-632.

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Abstract

Progressive skeletal muscle wasting is a natural consequence of aging and is common in chronic and acute diseases. Loss of skeletal muscle mass and function (strength) often leads to frailty, decreased independence and increased risk of hospitalization. Despite progress made in our understanding of mechanisms underlying muscle wasting, there is still no treatment available, with exercise training and dietary supplementation improving, but not restoring muscle mass and/or function. There has been slow progress in developing novel therapies for muscle wasting, either during aging or disease, partially due to the complex nature of processes underlying muscle loss. The mechanisms of muscle wasting are multifactorial, with a combination of factors underlying age- and disease-related functional muscle decline. These factors include well characterized changes in muscle such as changes in protein turnover, and more recently described mechanisms such as autophagy or satellite cell senescence. Advances in transcriptomics and other high-throughput approaches have highlighted significant deregulation of skeletal muscle gene and protein levels during aging and disease. These changes are regulated at different levels, including post-transcriptional gene expression regulation by microRNAs. microRNAs, potent regulators of gene expression, modulate many processes in muscle, and microRNA-based interventions have been recently suggested as a promising new therapeutic strategy against alterations in muscle homeostasis. Here, we review recent developments in understanding the aging-associated mechanisms of muscle wasting and explore potential microRNA-based therapeutic avenues.

Item Type:	Article
Uncontrolled Keywords:	fibro-adipogenic progenitors, microRNAs, muscle aging, sarcopenia, satellite cells, senescence
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	13 Feb 2023 16:44
Last Modified:	13 Feb 2023 16:44
DOI:	10.1152/japplphysiol.00961.2018
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3168389