Ngwili, N, Sentamu, DN, Korir, M, Adriko, M, Beinamaryo, P, Dione, MM, Moriku Kaducu, J, Mubangizi, A, Mwinzi, PN, Thomas, LF 
ORCID: 0000-0001-8447-1210 et al (show 1 more authors)
(2023)
Spatial and Temporal Distribution of Taenia solium and its Risk Factors in Uganda.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 129.
S1201-9712(23)00048-6-S1201-9712(23)00048-6.
Abstract
<h4>Background</h4>The lack of sub-national mapping of the zoonotic cestode Taenia solium in endemic countries presents a major challenge to achieving intensified T. solium control milestones, as outlined in the "World Health Organization neglected tropical disease roadmap by 2030". We conducted a mapping study in Uganda, considered to be endemic, to identify sub-national high-risk areas.<h4>Methods</h4>T. solium prevalence data, adjusted for diagnostic sensitivity and specificity in a Bayesian Framework, were identified through a systematic review. Spatial autocorrelation and interpolation techniques were used to transform Demographic and Health Survey cluster-level sanitation and poverty indicators, overlaid onto a pig density map for Uganda into modelled porcine cysticercosis (PCC) risk maps.<h4>Findings</h4>Sixteen articles (n = 11 PCC and n = 5 human cysticercosis (HCC) and/or human taeniasis) were included in the final analysis. HCC observed prevalence ranged from 0.01% - 6.0 % (Confidence Interval (CI) range: 0.004 - 11.4%), while adjusted PCC ranged from 0.3 - 93.9% (uncertainty interval range: 0 - 99.8%). There was substantial variation in the modelled PCC risk factors and prevalence across Uganda and over time.<h4>Interpretation</h4>High PCC prevalence and moderate HCC exposure estimates indicate the need for urgent implementation of T. solium control efforts in Uganda.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Taenia solium, Risk factor mapping, Spatial statistics, One Health, Zoonotic diseases, Neglected tropical diseases |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 03 Mar 2023 11:15 |
| Last Modified: | 10 Apr 2023 15:29 |
| DOI: | 10.1016/j.ijid.2023.02.001 |
| Open Access URL: | https://doi.org/10.1016/j.ijid.2023.02.001 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3168734 |
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