The biology of symptom-based disorders-time to act



Goebel, Andreas ORCID: 0000-0002-3763-8206, Andersson, David and Shoenfeld, Yehuda
(2023) The biology of symptom-based disorders-time to act. AUTOIMMUNITY REVIEWS, 22 (1). 103218-.

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Abstract

Symptom-based disorders are conditions that are characterised mostly by somatic symptoms rather than objectively identifiable signs. They are very common, including pain and fatigue disorders, functional gastrointestinal and respiratory disorders, and others, and they cause far greater disability than diseases where signs are prominent. Such conditions may sometimes be triggered by infection, as in Post Covid Syndrome (Cabral-Marques et al., 2022; Baiocchi et al., 2022) or physical or psychological trauma. By employing passive immunoglobulin transfer experimental approaches, recent research in several 'unexplained' chronic pain conditions has demonstrated that pathogenic IgG autoantibodies can explain several of these conditions' core symptoms and are ubiquitous in patients with severe phenotypes. The promise from placing positive resources into exploring the role of 'invisible', functional, non-inflammatory autoantibodies in symptom-based disorders across additional areas of Medicine includes patient empowerment and the development of new diagnostic tests and therapies.

Item Type: Article
Uncontrolled Keywords: Chronic pain, Fibromyalgia, Autoimmune, Autoantibody, Symptom-based disorder
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 17 Mar 2023 10:50
Last Modified: 22 Oct 2023 01:30
DOI: 10.1016/j.autrev.2022.103218
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3169140