The ALBI score: From liver function in patients with HCC to a general measure of liver function

Toyoda, Hidenori and Johnson, Philip J ORCID: 0000-0003-1404-0209 (2022) The ALBI score: From liver function in patients with HCC to a general measure of liver function. JHEP REPORTS, 4 (10). 100557-.

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Official URL: http://dx.doi.org/10.1016/j.jhepr.2022.100557

Abstract

The (albumin-bilirubin) 'ALBI' score is an index of 'liver function' that was recently developed to assess prognosis in patients with hepatocellular carcinoma, irrespective of the degree of underlying liver fibrosis. Other measures of liver function, such as model for end-stage liver disease (MELD) and Child-Pugh score, which were introduced for specific clinical scenarios, have seen their use extended to other areas of hepatology. In the case of ALBI, its application has been increasingly extended to chronic liver disease in general and in some instances to non-liver diseases where it has proven remarkably accurate in terms of prognosis. With respect to chronic liver disease, numerous publications have shown that ALBI is highly prognostic in patients with all types and stages of chronic liver disease. Outside of liver disease, ALBI has been reported as being of prognostic value in conditions ranging from chronic heart failure to brain tumours. Whilst in several of these reports, explanations for the relationship of liver function to a clinical condition have been proposed, it has to be acknowledged that the specificity of ALBI for liver function has not been clearly demonstrated. Nonetheless, and similar to the MELD and Child-Pugh scores, the lack of any mechanistic basis for ALBI's clinical utility does not preclude it from being clinically useful in certain situations. Why albumin and bilirubin levels, or a combination thereof, are prognostic in so many different diseases should be studied in the future.

Item Type:	Article
Uncontrolled Keywords:	liver function, liver fibrosis, hepatocellular carcinoma, liver-related dis-eases, non-liver-related dis-eases, prognosis
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	24 Mar 2023 11:52
Last Modified:	24 Mar 2023 11:52
DOI:	10.1016/j.jhepr.2022.100557
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3169231