All-cause and liver-related mortality risk factors in excessive drinkers: Analysis of data from the UK biobank.

Whitfield, John B ORCID: 0000-0002-1103-0876, Seth, Devanshi ORCID: 0000-0001-5614-1599, Morgan, Timothy R ORCID: 0000-0003-1328-0307 and GenomALC Consortium, (2022) All-cause and liver-related mortality risk factors in excessive drinkers: Analysis of data from the UK biobank. Alcoholism, clinical and experimental research, 46 (12). pp. 2245-2257.

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Official URL: http://dx.doi.org/10.1111/acer.14968

Abstract

<h4>Background</h4>High alcohol intake is associated with increased mortality. We aimed to identify factors affecting mortality in people drinking extreme amounts of alcohol.<h4>Methods</h4>We obtained information from the UK Biobank on approximately 500,000 participants aged 40-70 years at baseline assessment in 2006-2010. Habitual alcohol intake, lifestyle and physiological data, laboratory test results, and hospital diagnoses and death certificate data (to June 2020) for 5136 men (2.20% of male participants) and 1504 women (0.60%) who reported consuming ≥80 or ≥50 g/day, respectively, were used in survival analysis.<h4>Results</h4>Mortality hazard ratios for these excessive drinkers, compared to all other participants, were 2.02 (95% CI 1.89-2.17) for all causes, 1.89 (1.69-2.12) for any cancer, 1.87 (1.61-2.17) for any circulatory disease, and 9.40 (7.00-12.64) for any liver disease. Liver disease diagnosis or abnormal liver function tests predicted not only deaths attributed to liver disease but also those from cancers or circulatory diseases. Mortality among excessive drinkers was also associated with quantitative alcohol intake; diagnosed alcohol dependence, harmful use, or withdrawal syndrome; and current smoking at assessment.<h4>Conclusions</h4>People with chronic excessive alcohol intake experience decreased average survival, but there is substantial variation in their mortality, with liver abnormality and alcohol dependence or other alcohol use disorders associated with a worse prognosis. Clinically, patients with these risk factors and high alcohol intake should be considered for early or intensive management. Research can usefully focus on the factors predisposing to dependence or liver abnormality.

Item Type:	Article
Uncontrolled Keywords:	GenomALC Consortium, Liver, Humans, Cardiovascular Diseases, Alcoholism, Risk Factors, Alcohol Drinking, Biological Specimen Banks, Female, Male, United Kingdom
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	28 Mar 2023 08:22
Last Modified:	15 Apr 2023 13:10
DOI:	10.1111/acer.14968
Open Access URL:	https://doi.org/10.1111/acer.14968
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3169276