Bacteraemia variation during the COVID-19 pandemic; a multi-centre UK secondary care ecological analysis

Denny, Sarah, Rawson, Timothy M ORCID: 0000-0002-2630-9722, Hart, Peter, Satta, Giovanni, Abdulaal, Ahmed, Hughes, Stephen, Gilchrist, Mark, Mughal, Nabeela and Moore, Luke SP (2021) Bacteraemia variation during the COVID-19 pandemic; a multi-centre UK secondary care ecological analysis. BMC INFECTIOUS DISEASES, 21 (1). 556-.

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Official URL: http://dx.doi.org/10.1186/s12879-021-06159-8

Abstract

<h4>Background</h4>We investigated for change in blood stream infections (BSI) with Enterobacterales, coagulase negative staphylococci (CoNS), Streptococcus pneumoniae, and Staphylococcus aureus during the first UK wave of SARS-CoV-2 across five London hospitals.<h4>Methods</h4>A retrospective multicentre ecological analysis was undertaken evaluating all blood cultures taken from adults from 01 April 2017 to 30 April 2020 across five acute hospitals in London. Linear trend analysis and ARIMA models allowing for seasonality were used to look for significant variation.<h4>Results</h4>One hundred nineteen thousand five hundred eighty-four blood cultures were included. At the height of the UK SARS-CoV-2 first wave in April 2020, Enterobacterales bacteraemias were at an historic low across two London trusts (63/3814, 1.65%), whilst all CoNS BSI were at an historic high (173/3814, 4.25%). This differed significantly for both Enterobacterales (p = 0.013), CoNS central line associated BSIs (CLABSI) (p < 0.01) and CoNS non-CLABSI (p < 0.01), when compared with prior periods, even allowing for seasonal variation. S. pneumoniae (p = 0.631) and S. aureus (p = 0.617) BSI did not vary significant throughout the study period.<h4>Conclusions</h4>Significantly fewer than expected Enterobacterales BSI occurred during the UK peak of the COVID-19 pandemic; identifying potential causes, including potential unintended consequences of national self-isolation public health messaging, is essential. High rates of CoNS BSI, with evidence of increased CLABSI, but also likely contamination associated with increased use of personal protective equipment, may result in inappropriate antimicrobial use and indicates a clear area for intervention during further waves.

Item Type:	Article
Uncontrolled Keywords:	Microbiology, Blood culture, Coronavirus, SARS-CoV-2
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	28 Mar 2023 08:52
Last Modified:	28 Mar 2023 08:53
DOI:	10.1186/s12879-021-06159-8
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3169281