McLeod, James, Stadler, Ellen, Wilson, Richard 
ORCID: 0000-0002-3275-6932, Holmes, Alison ORCID: 0000-0001-5554-5743 and O'Hare, Danny
(2021)
Electrochemical detection of cefiderocol for therapeutic drug monitoring.
ELECTROCHEMISTRY COMMUNICATIONS, 133.
p. 107147.
Abstract
Cefiderocol is a novel siderophore-conjugated β-lactam antibiotic which has been approved for clinical use. It has demonstrated efficacy against infections caused by Gram-negative bacteria, including carbapenem-resistant strains. Novel antibiotics are rarely brought to market and, as such, are ideal candidates for therapeutic drug monitoring which enables optimised dosing across a range of clinical scenarios whilst also reducing the chances of antimicrobial resistance. Here we demonstrate direct electrochemical detection of cefiderocol by oxidation using untreated gold and glassy carbon electrodes as well as multi-walled carbon nanotube (MWCNT)-coated glassy carbon and foamed gold electrodes. Quantification of cefiderocol in the therapeutic range is demonstrated in spiked whole human blood using MWCNT-coated pyrolytic carbon screen-printed electrodes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Antimicrobial resistance, Cefiderocol |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 28 Mar 2023 11:05 |
| Last Modified: | 28 Mar 2023 11:05 |
| DOI: | 10.1016/j.elecom.2021.107147 |
| Open Access URL: | https://doi.org/10.1016/j.elecom.2021.107147 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3169301 |
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