Bengtsson, Rebecca J, Baker, Kate S 
ORCID: 0000-0001-5850-1949, Cunningham, Andrew A ORCID: 0000-0002-3543-6504, Greig, David R ORCID: 0000-0001-9436-067X, John, Shinto K, Macgregor, Shaheed K, Seilern-Moy, Katharina, Spiro, Simon, Chong, Charlotte C, De Silva, P Malaka ORCID: 0000-0002-0579-0131 et al (show 2 more authors)
(2023)
The genomic epidemiology of Escherichia albertii infecting humans and birds in Great Britain.
Nature communications, 14 (1).
1707-.
Abstract
Escherichia albertii is a recently identified gastrointestinal bacterial pathogen of humans and animals which is typically misidentified as pathotypes of diarrhoeagenic Escherichia coli or Shigella species and is generally only detected during genomic surveillance of other Enterobacteriaceae. The incidence of E. albertii is likely underestimated, and its epidemiology and clinical relevance are poorly characterised. Here, we whole genome sequenced E. albertii isolates from humans (n = 83) and birds (n = 79) isolated in Great Britain between 2000 and 2021 and analysed these alongside a broader public dataset (n = 475) to address these gaps. We found human and avian isolates typically (90%; 148/164) belonged to host-associated monophyletic groups with distinct virulence and antimicrobial resistance profiles. Overlaid patient epidemiological data suggested that human infection was likely related to travel and possibly foodborne transmission. The Shiga toxin encoding stx2f gene was associated with clinical disease (OR = 10.27, 95% CI = 2.98-35.45 p = 0.0002) in finches. Our results suggest that improved future surveillance will further elucidate disease ecology and public and animal health risks associated with E. albertii.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Animals, Birds, Humans, Escherichia coli, Enterobacteriaceae Infections, Escherichia coli Infections, Genomics, United Kingdom |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 31 Mar 2023 14:59 |
| Last Modified: | 29 Apr 2023 00:54 |
| DOI: | 10.1038/s41467-023-37312-3 |
| Open Access URL: | https://doi.org/10.1038/s41467-023-37312-3 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3169403 |
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