Clinical Phenotypes and Atrial Fibrillation Recurrences after Catheter Ablation: An Unsupervised Cluster Analysis.

Bisson, Arnaud ORCID: 0000-0002-3449-1800, Fawzy, Ameenathul M, El-Bouri, Wahbi ORCID: 0000-0002-2732-5927, Angoulvant, Denis, Lip, Gregory YH ORCID: 0000-0002-7566-1626, Fauchier, Laurent and Clementy, Nicolas (2023) Clinical Phenotypes and Atrial Fibrillation Recurrences after Catheter Ablation: An Unsupervised Cluster Analysis. Current problems in cardiology, 48 (8). p. 101732.

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Official URL: http://dx.doi.org/10.1016/j.cpcardiol.2023.101732

Abstract

Catheter ablation (CA) is a well-established treatment of atrial fibrillation (AF). Data-driven cluster analysis is able to better distinguish prognostically-relevant phenotype clusters among patients with AF. We performed a hierarchical cluster analysis in a cohort of AF patients undergoing a first CA and evaluate associations between identified clusters and recurrences of arrhythmia following ablation. The study included 209 AF patients treated with CA. 3 clusters with distinct characteristics were identified. Recurrences at one year occurred in 27.2% in Cluster 1, 43.2% in Cluster 2 and 60.9% in Cluster 3 (p<0.0001). Cluster classification was independently associated with arrhythmia recurrences (HR 1.58, 95% CI 1.01-2.49, p=0.046) after adjustment for age, CHA<sub>2</sub>DS<sub>2</sub>-VASc score, left atrial volume, type of atrial fibrillation and ejection fraction. To concluded, cluster analysis identified three statistically-driven groups among AF patients treated with CA with different risks for arrhythmia recurrences.

Item Type:	Article
Uncontrolled Keywords:	Humans, Atrial Fibrillation, Recurrence, Catheter Ablation, Treatment Outcome, Cluster Analysis, Risk Assessment, Risk Factors, Predictive Value of Tests
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	12 Apr 2023 09:58
Last Modified:	31 Mar 2024 01:30
DOI:	10.1016/j.cpcardiol.2023.101732
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3169540