Brown, Stephen L 
ORCID: 0000-0002-6142-0995, Hope-Stone, Laura ORCID: 0000-0001-6069-7231 and Cherry, Mary Gemma
(2023)
Seven-Year Distress Trajectories in Uveal Melanoma Survivors.
HEALTH PSYCHOLOGY, 42 (4).
pp. 247-256.
|
Text
HEA-2022-3826_R2.pdf - Author Accepted Manuscript Download (2MB) | Preview |
Abstract
<h4>Objective</h4>Severe or persistent distress is associated with poorer quality of life in cancer survivors. Distress follows distinct trajectories within different population subgroups. Identifying characteristics and causes of trajectories can assist intervention development and targeting. In a 7-year study of uveal melanoma survivors, we aimed to characterize anxiety, depression, and fear of cancer recurrence (FCR) trajectories, and identify whether concerns about symptoms and functional problems over the first 3 years of survivorship predict memberships of high distress trajectories.<h4>Method</h4>In a closed cohort study, we used growth mixture modeling (GMM) to identify statistically optimal trajectories over 6-, 12-, 24-, 36-, 48-, 60-, 72-, and 84-month time point posttreatment in 475 patients. We then regressed trajectory memberships onto a 3-year series of measures of concerns about symptoms and functional problems, controlling demographic, clinical, and 6-month anxiety, depression, or FCR indicators.<h4>Results</h4>Anxiety, depression, and FCR were represented by two-class linear GMMs. The majority scored consistently low, but 17.5% showed consistently elevated anxiety, 10.9% consistently elevated depression, and 19.4% consistently elevated FCR. Higher anxiety trajectory membership was predicted by greater concerns about symptoms at 6 and 24 months, higher depression trajectory membership by symptoms at 24 months, and higher FCR trajectory membership by symptoms at 6 and 24 months and functional problems at 12 months.<h4>Conclusions</h4>Much of the burden of persistent distress in cancer patients falls on a small proportion of survivors. Concerns about symptoms and functional problems are potential risk factors for distress. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cancer survivorship, fear of cancer recurrence, growth mixture modeling, psychological distress, uveal melanoma |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 13 Apr 2023 07:28 |
| Last Modified: | 14 Apr 2023 03:47 |
| DOI: | 10.1037/hea0001270 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3169543 |
Dimensions
Dimensions
