Li, Shun, Pritchard, David Mark 
ORCID: 0000-0001-7971-3561 and Yu, Lu-Gang ORCID: 0000-0001-9641-3712
(2023)
Galectin-3 promotes secretion of proteases that decrease epithelium integrity in human colon cancer cells.
CELL DEATH & DISEASE, 14 (4).
268-.
Abstract
Galectin-3 is a galactoside-binding protein that is commonly overexpressed in many epithelial cancers. It is increasingly recognized as a multi-functional, multi-mode promoter in cancer development, progression, and metastasis. This study reports that galectin-3 secretion by human colon cancer cells induces cancer cell secretion, in an autocrine/paracrine manner, of a number of proteases including cathepsin-B, MMP-1 and MMP-13. The secretion of these proteases causes disruption of epithelial monolayer integrity, increases its permeability and promotes tumour cell invasion. This effect of galectin-3 is shown to be mediated through induction of cellular PYK2-GSK3α/β signalling and can be prevented by the presence of galectin-3 binding inhibitors. This study thus reveals an important mechanism in galectin-3-mediated promotion of cancer progression and metastasis. It provides further evidence to the increased realization of galectin-3 as a potential therapeutic target for the treatment of cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Epithelium, Humans, Colonic Neoplasms, Peptide Hydrolases, Galectin 3 |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 14 Apr 2023 10:39 |
| Last Modified: | 02 Jun 2023 08:40 |
| DOI: | 10.1038/s41419-023-05789-x |
| Open Access URL: | https://doi.org/10.1038/s41419-023-05789-x |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3169563 |
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