Damodar, Tina, Singh, Bhagteshwar 
ORCID: 0000-0002-9039-3674, Prabhu, Namratha, Marate, Srilatha, Gowda, Vykuntaraju K, Lalitha, AV, Dsouza, Fulton Sebastian, Sajjan, Sushma Veeranna, Kariyappa, Mallesh, Kinhal, Uddhava V et al (show 6 more authors)
(2023)
Association of Scrub Typhus in Children with Acute Encephalitis Syndrome and Meningoencephalitis, Southern India.
Emerging Infectious Diseases, 29 (4).
pp. 711-722.
Abstract
Scrub typhus is an established cause of acute encephalitis syndrome (AES) in northern states of India. We systematically investigated 376 children with AES in southern India, using a stepwise diagnostic strategy for the causative agent of scrub typhus, Orientia tsutsugamushi, including IgM and PCR testing of blood and cerebrospinal fluid (CSF) to grade its association with AES. We diagnosed scrub typhus in 87 (23%) children; of those, association with AES was confirmed in 16 (18%) cases, probable in 55 (63%), and possible in 16 (18%). IgM detection in CSF had a sensitivity of 93% and specificity of 82% compared with PCR. Our findings suggest scrub typhus as an emerging common treatable cause of AES in children in southern India and highlight the importance of routine testing for scrub typhus in diagnostic algorithms. Our results also suggest the potential promise of IgM screening of CSF for diagnosis of AES resulting from scrub typhus.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Orientia tsutsugamushi, Scrub Typhus, Meningoencephalitis, Immunoglobulin M, Child, India, Acute Febrile Encephalopathy |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 17 Apr 2023 07:58 |
| Last Modified: | 11 Oct 2023 14:48 |
| DOI: | 10.3201/eid2904.221157 |
| Open Access URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3169569 |
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