Mucosal-Associated Invariant T (MAIT) Cells Are Impaired in Th17 Associated Primary and Secondary Immunodeficiencies

Gao, Yifang, Rae, William, Ramakrishnan, Keseva Ananth, Barcenas-Morales, Gabriela, Doffinger, Rainer, Eren, Efrem, Faust, Saul N, Ottensmeier, Christian H ORCID: 0000-0003-3619-1657 and Williams, Anthony P (2016) Mucosal-Associated Invariant T (MAIT) Cells Are Impaired in Th17 Associated Primary and Secondary Immunodeficiencies. PLOS ONE, 11 (5). e0155059-.

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Official URL: http://dx.doi.org/10.1371/journal.pone.0155059

Abstract

The recently described Mucosal Associated Invariant T (MAIT) cells mediate specific recognition of bacterial and fungal vitamin B2 metabolites. As innate T cells, they possess broad effector responses, including IFN- including Iproduction, that are comparable to conventional T cell responses. Immunodeficiencies associated with systemic Th17 deficiency may also be compounded by defects in MAIT immunity. We evaluated Th17 immunity in this innate T cell compartment in primary (AD-HIES) and secondary immunodeficiency (thymoma) patients with conventional Th17 deficiency and susceptibility to fungal and bacterial disease. Our results suggest that MAIT cells are both reduced and functional deficient in STAT3 deficiency and thymoma patients with IL-12/23 autoantibodies. In contrast, thymoma patients without autoantibodies preserved the normal number and functional MAIT cells.

Item Type:	Article
Uncontrolled Keywords:	Intracellular Space, Humans, Immunologic Deficiency Syndromes, Cytokines, Case-Control Studies, Adult, Aged, Middle Aged, Female, Male, Th17 Cells, Mucosal-Associated Invariant T Cells
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	19 Apr 2023 09:23
Last Modified:	19 Apr 2023 09:23
DOI:	10.1371/journal.pone.0155059
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3169670