Chemoselective Decarboxylative Oxygenation of Carboxylic Acids To Access Ketones, Aldehydes, and Peroxides

Guan, Renpeng, Chen, Guanhong, Bennett, Elliot L ORCID: 0000-0003-3798-4296, Huang, Zhiliang and Xiao, Jianliang ORCID: 0000-0003-2010-247X (2023) Chemoselective Decarboxylative Oxygenation of Carboxylic Acids To Access Ketones, Aldehydes, and Peroxides. ORGANIC LETTERS, 25 (14). pp. 2482-2486.

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Official URL: http://dx.doi.org/10.1021/acs.orglett.3c00649

Abstract

Reported here is a photocatalytic strategy for the chemoselective decarboxylative oxygenation of carboxylic acids using Ce(III) catalysts and O<sub>2</sub> as the oxidant. By simply changing the base employed, we demonstrate that the selectivity of the reaction can be channeled to favor hydroperoxides or carbonyls, with each class of products obtained in good to excellent yields and high selectivity. Notably, valuable ketones, aldehydes, and peroxides are produced directly from readily available carboxylic acid without additional steps.

Item Type:	Article
Divisions:	Faculty of Science and Engineering > School of Physical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	19 Apr 2023 09:09
Last Modified:	19 Oct 2023 10:31
DOI:	10.1021/acs.orglett.3c00649
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3169718