Ni(I)-Catalyzed Hydroxylation of Aryl Halides with Water under Thermal Catalysis

Yang, Liu, Yan, Yonggang, Cao, Ni, Hao, Jing, Li, Gang, Zhang, Wei, Cao, Rui, Wang, Chao, Xiao, Jianliang ORCID: 0000-0003-2010-247X and Xue, Dong (2022) Ni(I)-Catalyzed Hydroxylation of Aryl Halides with Water under Thermal Catalysis. ORGANIC LETTERS, 24 (51). pp. 9431-9435.

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Official URL: http://dx.doi.org/10.1021/acs.orglett.2c03840

Abstract

A highly efficient hydroxylation of (hetero)aryl halides using water as a hydroxyl source via Ni catalysis promoted by PhSiH<sub>3</sub> under thermal catalysis is reported. This methodology provides a general procedure to obtain diverse multifunctional pharmaceutically phenols and polyphenols, some of which are proven challenging to be synthesized using literature methods. Mechanism studies demonstrated that the addition of PhSiH<sub>3</sub> led to the generation of active Ni(I) species, which catalyze the hydroxylation via a Ni(I)-Ni(III) pathway.

Item Type:	Article
Divisions:	Faculty of Science and Engineering > School of Physical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	19 Apr 2023 09:08
Last Modified:	19 Dec 2023 02:30
DOI:	10.1021/acs.orglett.2c03840
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3169719