Protocol for the CoNoR Study: A prospective multi-step study of the potential added benefit of two novel assessment tools in colorectal liver metastases technical resectability decision-making.


Parmar, Kat L ORCID: 0000-0003-1414-6724, O'Reilly, Derek, Valle, Juan, Braun, Michael, Malcomson, Lee, Jones, Robert P ORCID: 0000-0001-5608-001X, Balaa, Fady, Rees, Myrddin, Welsh, Fenella KS, Filobbos, Rafik et al (show 1 more authors) (2023) Protocol for the CoNoR Study: A prospective multi-step study of the potential added benefit of two novel assessment tools in colorectal liver metastases technical resectability decision-making. BMJ open, 13 (3). e059369-.

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Abstract

<h4>Introduction</h4>Liver resection is the only curative treatment for colorectal liver metastases (CLM). Resectability decision-making is therefore a key determinant of outcomes. Wide variation has been demonstrated in resectability decision-making, despite the existence of criteria. This paper summarises a study protocol to evaluate the potential added value of two novel assessment tools in assessing CLM technical resectability: the Hepatica preoperative MR scan (MR-based volumetry, Couinaud segmentation, liver tissue characteristics and operative planning tool) and the LiMAx test (hepatic functional capacity).<h4>Methods and analysis</h4>This study uses a systematic multistep approach, whereby three preparatory workstreams aid the design of the final international case-based scenario survey:Workstream 1: systematic literature review of published resectability criteria.Workstream 2: international hepatopancreatobiliary (HPB) interviews.Workstream 3: international HPB questionnaire.Workstream 4: international HPB case-based scenario survey.The primary outcome measures are change in resectability decision-making and change in planned operative strategy, resulting from the novel test results. Secondary outcome measures are variability in CLM resectability decision-making and opinions on the role for novel tools.<h4>Ethics and dissemination</h4>The study protocol has been approved by a National Health Service Research Ethics Committee and registered with the Health Research Authority. Dissemination will be via international and national conferences. Manuscripts will be published.<h4>Registration details</h4>The CoNoR Study is registered with ClinicalTrials.gov (registration number NCT04270851). The systematic review is registered on the PROSPERO database (registration number CRD42019136748).

Item Type: Article
Uncontrolled Keywords: Humans, Colorectal Neoplasms, Liver Neoplasms, Prospective Studies, State Medicine, Systematic Reviews as Topic
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 19 Apr 2023 10:14
Last Modified: 19 Apr 2023 10:14
DOI: 10.1136/bmjopen-2021-059369
Open Access URL: https://bmjopen.bmj.com/content/13/3/e059369
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3169733
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