Weller, Michael, Le Rhun, Emilie, Van den Bent, Martin, Chang, Susan M, Cloughesy, Timothy F, Goldbrunner, Roland, Hong, Yong-Kil, Jalali, Rakesh, Jenkinson, Michael D 
ORCID: 0000-0003-4587-2139, Minniti, Giuseppe et al (show 8 more authors)
(2023)
Diagnosis and management of complications from the treatment of primary central nervous system tumors in adults.
Neuro-oncology, 25 (7).
noad038-noad038.
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Abstract
Central nervous system (CNS) tumor patients commonly undergo multimodality treatment in the course of their disease. Adverse effects and complications from these interventions have not been systematically studied, but pose significant challenges in clinical practice and impact function and quality of life, especially in the management of long-term brain tumor survivors. Here the European Association of Neuro-Oncology (EANO) has developed recommendations to prevent, diagnose and manage adverse effects and complications in the adult primary brain CNS tumor (except lymphomas) patient population with a specific focus on surgery, radiotherapy and pharmacotherapy. Specifically, we also provide recommendations for dose adaptations, interruptions and re-exposure for pharmacotherapy that may serve as a reference for the management of standard of care in clinical trials. We also summarize which interventions are unnecessary, inactive or contraindicated. This consensus paper should serve as a reference for the conduct of standard therapy within and outside of clinical trials.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | adverse affects, dose, interruptions, prevention, reexposure, toxicity |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 20 Apr 2023 08:23 |
| Last Modified: | 08 Jul 2023 00:50 |
| DOI: | 10.1093/neuonc/noad038 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3169789 |
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