Subtherapeutic Exposure of Ganciclovir in Children Despite Appropriate Dosing: A Short Communication

Marfil, Sjanene, Maertson, Anne-Grete, Toren-Wielema, Marlous, Leer-Buter, Coretta, Scholvinck, Elisabeth H, Alffenaar, Jan-Willem C, Touw, Daan J and Sturkenboom, Marieke GG (2023) Subtherapeutic Exposure of Ganciclovir in Children Despite Appropriate Dosing: A Short Communication. THERAPEUTIC DRUG MONITORING, 45 (2). pp. 269-272.

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Official URL: http://dx.doi.org/10.1097/ftd.0000000000001050

Abstract

<h4>Abstract</h4>Therapeutic drug monitoring (TDM) results for ganciclovir in 12 different treatment episodes showed large intraindividual and interindividual variabilities in the trough concentration and area under the 24-hour concentration-time curve (AUC24). Despite adequate valganciclovir dosing, subtherapeutic concentrations were found in 30% of the treatment episodes. A decrease in viral load was observed regardless of subtherapeutic exposure. These findings show the need for target concentration evaluation and assessment of the applicability of ganciclovir TDM in children.

Item Type:	Article
Uncontrolled Keywords:	ganciclovir, valganciclovir, therapeutic drug monitoring, cytomegalovirus
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	21 Apr 2023 09:12
Last Modified:	21 Apr 2023 09:12
DOI:	10.1097/FTD.0000000000001050
Open Access URL:	http://10.0.4.73/FTD.0000000000001050
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3169821